Document Detail

New developments on thromboxane modulators.
MedLine Citation:
PMID:  15279599     Owner:  NLM     Status:  MEDLINE    
Thromboxane A(2) (TXA(2)) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA(2) modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA(2) modulators.
Jean-Michel Dogné; Julien Hanson; Xavier de Leval; Bernard Masereel; Philippe Kolh; Bernard Pirotte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mini reviews in medicinal chemistry     Volume:  4     ISSN:  1389-5575     ISO Abbreviation:  Mini Rev Med Chem     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2004-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101094212     Medline TA:  Mini Rev Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  649-57     Citation Subset:  IM    
Natural and Synthetic Drug Research Centre, Medicinal Chemistry, University of Liège, 1, av. de l'Hôpital, B-4000 Liège, Belgium.
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MeSH Terms
Enzyme Inhibitors / pharmacology
Receptors, Thromboxane / agonists,  antagonists & inhibitors*,  chemistry
Signal Transduction
Thromboxane A2 / antagonists & inhibitors*,  metabolism
Thromboxane-A Synthase / antagonists & inhibitors*
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Receptors, Thromboxane; 57576-52-0/Thromboxane A2; EC Synthase

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