Document Detail


New developments in telomere length analysis.
MedLine Citation:
PMID:  15919587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telomeres provide an essential 'capping' function, which prevents the natural end of a chromosome from being recognised as a simple dsDNA break. The biology of human telomeres is inextricably linked with both cancer and ageing. As such there is considerable interest in determining the length of these essential and dynamic structures. Here I review, from the standpoint of ageing research in humans, the current situation with regards to technologies available to determine telomere length in human cells and tissues.
Authors:
Duncan M Baird
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-03-29
Journal Detail:
Title:  Experimental gerontology     Volume:  40     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-27     Completed Date:  2005-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. bairddm@cardiff.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
DNA / genetics
Humans
In Situ Hybridization, Fluorescence / methods
Polymerase Chain Reaction / methods
Restriction Mapping / methods
Telomere / genetics*
Chemical
Reg. No./Substance:
9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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