| New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy. | |
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MedLine Citation:
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PMID: 22205621 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Infection with hepatitis C virus (HCV) affects approximately 170 million people worldwide. However, no vaccine or immunoglobulin is currently available for the prevention of HCV infection. The standard of care (SOC) involving pegylated interferon-α (PEG-IFN α) plus ribavirin (RBV) for 48 weeks results in a sustained virologic response in less than 50% of patients with chronic hepatitis C genotype 1, the most prevalent type of HCV in North America and Europe. Recently, reliable in vitro culture systems have been developed for accelerating antiviral therapy research, and many new specifically targeted antiviral therapies for hepatitis C (STAT-C) and treatment strategies are being evaluated in clinical trials. These new antiviral agents are expected to improve present treatment significantly and may potentially shorten treatment duration. The aim of this review is to summarize the current developments in new anti-HCV drugs. |
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Authors:
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Jing Tong; You-Wei Wang; Yuan-An Lu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Zhejiang University. Science. B Volume: 13 ISSN: 1862-1783 ISO Abbreviation: J Zhejiang Univ Sci B Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236535 Medline TA: J Zhejiang Univ Sci B Country: China |
Other Details:
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Languages: eng Pagination: 56-82 Citation Subset: IM |
Affiliation:
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Department of Public Health Sciences, University of Hawaii, Honolulu, Hawaii 96822, USA; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Institute of Traditional Chinese Medicine & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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