| New developments in the regulation of intestinal copper absorption. | |
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MedLine Citation:
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PMID: 19906252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transition metal copper is an essential trace element involved in many enzymatic processes that require redox-chemistry. The redox-activity of copper is potentially harmful. Severe imbalance of copper homeostasis can occur with some hereditary disorders of copper metabolism. Copper is acquired from the diet by intestinal absorption and is subsequently distributed throughout the body. The regulation of intestinal copper absorption to maintain whole-body copper homeostasis is currently poorly understood. This review evaluates novel findings regarding the molecular mechanism of intestinal copper uptake. The role of recently identified transporters in enterocyte copper uptake and excretion into the portal circulation is described, and the regulation of dietary copper uptake during physiological and pathophysiological conditions is discussed. |
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Authors:
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Peter V E van den Berghe; Leo W J Klomp |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nutrition reviews Volume: 67 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-12 Completed Date: 2010-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 658-72 Citation Subset: IM |
Affiliation:
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Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Transport Ceruloplasmin / metabolism Copper / deficiency, metabolism, pharmacokinetics* Enterocytes / physiology* Hepatolenticular Degeneration / genetics Homeostasis Humans Intestinal Absorption / drug effects* Menkes Kinky Hair Syndrome / genetics Metallothionein / metabolism Oxidation-Reduction Trace Elements / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Trace Elements; 7440-50-8/Copper; 9038-94-2/Metallothionein; EC 1.16.3.1/Ceruloplasmin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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