Document Detail

New developments in the management of preterm labor.
MedLine Citation:
PMID:  11707016     Owner:  NLM     Status:  MEDLINE    
Current management of preterm labor has not changed the incidence of preterm delivery; therefore, significant research effort has been concentrated on the search for new methods of management. New tocolytics like inhibitors of cyclooxygenase 2 and nitric oxide donors have been tested in animal models and in preliminary clinical trials with promising results. Inhibition of cervical ripening may be one alternative to tocolysis. This new approach has a potential to be a valuable method of management of preterm labor if human studies confirm the promising results reported in animals. Growing evidence suggests that premature delivery may be associated with infection or fetal growth abnormalities, with dire consequences to the fetus. If these associations are to be included in risk and benefit assessment, then inhibition of preterm labor may prove to be detrimental to the fetus.
R Bukowski; G R Saade
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  25     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-14     Completed Date:  2002-02-28     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-94     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, USA.
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MeSH Terms
Cerebral Palsy / etiology
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / therapeutic use
Fetal Diseases / etiology
Infection / etiology
Ion Channel Gating / drug effects
Isoenzymes / antagonists & inhibitors
Membrane Proteins
Nitric Oxide Donors / therapeutic use
Obstetric Labor, Premature / complications,  drug therapy*
Potassium Channels / drug effects,  physiology
Prostaglandin-Endoperoxide Synthases
Risk Factors
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Membrane Proteins; 0/Nitric Oxide Donors; 0/Potassium Channels; EC 2; EC protein, human; EC Synthases

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