| New developments in the management of preterm labor. | |
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MedLine Citation:
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PMID: 11707016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Current management of preterm labor has not changed the incidence of preterm delivery; therefore, significant research effort has been concentrated on the search for new methods of management. New tocolytics like inhibitors of cyclooxygenase 2 and nitric oxide donors have been tested in animal models and in preliminary clinical trials with promising results. Inhibition of cervical ripening may be one alternative to tocolysis. This new approach has a potential to be a valuable method of management of preterm labor if human studies confirm the promising results reported in animals. Growing evidence suggests that premature delivery may be associated with infection or fetal growth abnormalities, with dire consequences to the fetus. If these associations are to be included in risk and benefit assessment, then inhibition of preterm labor may prove to be detrimental to the fetus. |
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Authors:
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R Bukowski; G R Saade |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 25 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-14 Completed Date: 2002-02-28 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 272-94 Citation Subset: IM |
Affiliation:
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Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Palsy
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etiology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors / therapeutic use Female Fetal Diseases / etiology Humans Infection / etiology Ion Channel Gating / drug effects Isoenzymes / antagonists & inhibitors Membrane Proteins Nitric Oxide Donors / therapeutic use Obstetric Labor, Premature / complications, drug therapy* Potassium Channels / drug effects, physiology Pregnancy Prostaglandin-Endoperoxide Synthases Risk Factors Tocolysis |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Membrane Proteins; 0/Nitric Oxide Donors; 0/Potassium Channels; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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