Document Detail


New developments in lipid emulsions for parenteral nutrition.
MedLine Citation:
PMID:  3119489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
More than one thousand publications have demonstrated the safety and efficacy of today's lipid emulsions including long chain fatty acids under experimental and clinical conditions. This has resulted in a general acceptance of a dual energy system comprising both carbohydrates and lipids as non-protein calories in total parenteral nutrition. Non-carnitine-dependent fatty acid has been suggested as a superior energy source in clinical situations where carnitine may be in the subnormal range. A medium chain triglyceride (MCT) emulsion would provide an energy source with a more readily oxidizable substrate. The tolerance of MCT is less than that of long chain triglyceride (LCT), whereby only physical mixtures of these emulsions will be used in humans. A structured lipid (SL) is a triglyceride which includes both medium and long chained fatty acids within the same triglyceride. Emulsions including SL have demonstrated a decreased protein energy expenditure and increased serum albumin in burned animal. The SL has also been superior to LCT emulsions in stimulating muscle protein synthesis and maintaining body weight in hepatectomized animals. These positive effects on protein kinetics have been concomitant with a lower RES involvement during septicemia in burned guinea pigs. Emulsions including fatty acids with odd-number carbons give a possibility to provide a fat emulsion which also could contribute positively to the glucose homeostasis. The omega-3 family of fatty acids has demonstrated a potential pharmacologic effect with regard to their ability to decrease blood viscosity and improve survival rate in endotoxin shock in an experimental model. These observations have been ascribed to changes in thromboxin A2 levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
L Ekman; A Wretlind; L Moldawer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Infusionstherapie und klinische Ernährung     Volume:  14 Suppl 3     ISSN:  0378-0791     ISO Abbreviation:  Infusionsther Klin Ernahr     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-12-24     Completed Date:  1987-12-24     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7613112     Medline TA:  Infusionsther Klin Ernahr     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  4-8     Citation Subset:  IM    
Affiliation:
Vitrum Institute for Human Nutrition, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Fat Emulsions, Intravenous / administration & dosage*
Fatty Acids / administration & dosage
Humans
Parenteral Nutrition, Total / trends*
Triglycerides / administration & dosage
Chemical
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Triglycerides

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