Document Detail


New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma.
MedLine Citation:
PMID:  17502044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wound healing and tissue repair, fibroblasts provide proinflammatory signals and synthesize interstitial collagens, fibronectins, and other matrix components to repair the damaged tissue. Fibroblasts can differentiate into the myofibroblast, a specialized contractile cell type responsible for wound closure, tissue contraction, and scarring. This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma.
Authors:
David J Abraham; Beate Eckes; Vineeth Rajkumar; Thomas Krieg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  9     ISSN:  1523-3774     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-15     Completed Date:  2007-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-43     Citation Subset:  IM    
Affiliation:
Department of Medicine, Royal Free and University College Medical School, University College London (Hampstead Campus), Rowland Hill Street, London NW3 2PF, United Kingdom. d.abraham@medsch.ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Cell Differentiation
Fibroblasts / pathology*
Fibrosis / pathology
Humans
Mesenchymal Stem Cells / cytology
Scleroderma, Systemic / etiology,  pathology*
Signal Transduction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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