| New developments in the discovery of small molecule Hedgehog pathway antagonists. | |
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MedLine Citation:
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PMID: 20399136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Hedgehog (Hh) signaling pathway is crucial for normal embryonic development. Aberrant Hh signaling is implicated in numerous pathologic conditions including proliferative diseases such as cancer. During the past decade, academic and industrial research efforts have resulted in the discovery of a variety of Hh pathway antagonists. This review focuses on the most recent advances in this field with particular emphasis on the medicinal chemistry approaches used to discover these Hh antagonists. While most of the small molecule modulators of the Hh pathway were discovered through screening and subsequent medicinal chemistry, a number of them originated from rational design or natural products. |
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Authors:
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Martin R Tremblay; Karen McGovern; Margaret A Read; Alfredo C Castro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 14 ISSN: 1879-0402 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 428-35 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Infinity Pharmaceuticals, Inc., 780 Memorial Drive, Cambridge, MA 02139, USA. martin.tremblay@infi.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug Discovery
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methods* Drug Evaluation, Preclinical / methods Hedgehog Proteins / antagonists & inhibitors* Humans Neoplasms / drug therapy Signal Transduction Small Molecule Libraries* |
| Chemical | |
Reg. No./Substance:
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0/Hedgehog Proteins; 0/Small Molecule Libraries |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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