Document Detail

New developments: chloroquine-resistance in Plasmodium falciparum.
MedLine Citation:
PMID:  11768327     Owner:  NLM     Status:  MEDLINE    
Chloroquine-resistance is associated with higher malaria mortality in children in Africa where the drug is still widely used. In sensitive strains the drug attacks hemoglobin digestion in the lysosome and prevents detoxification of hemin to hemozoin. Reduced drug uptake is responsible for resistance, which is incompletely associated with changes in lysosome membrane protein PGH1. The report discussed here gives evidence for the role of another lysosome membrane protein, PfCRT, where a change from lysine to threonine in a transmembrane domain determines the change to resistance. Other changes in PfCRT, and to some extent change(s) in PGH1, are believed to compensate for loss of fitness of the modified PfCRT.
D Warhurst
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy     Volume:  4     ISSN:  1368-7646     ISO Abbreviation:  Drug Resist. Updat.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-12-20     Completed Date:  2002-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9815369     Medline TA:  Drug Resist Updat     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
London School of Hygiene and Tropical Medicine, UK.
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MeSH Terms
Antimalarials / pharmacology,  therapeutic use
Chloroquine / pharmacology,  therapeutic use*
Drug Resistance* / genetics
Malaria, Falciparum / drug therapy*,  genetics,  metabolism
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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