Document Detail


New decalin derivatives, eujavanoic acids A and B, from Eupenicillium javanicum.
MedLine Citation:
PMID:  15387665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new decalin derivatives, eujavanoic acids A (1) and B (2), were isolated from Eupenicillium javanicum, along with several compactin derivatives. The structures of 1 and 2 were determined by spectroscopic methods and modified Mosher's method. The side chain (2-methylbutanoyloxy) and acid functionalities of compactin derivatives were necessary to show the antifungal activity.
Authors:
Shigeru Okamoto; Tomoo Hosoe; Takeshi Itabashi; Koohei Nozawa; Kaoru Okada; Galba Maria de Campos Takaki; Minoru Chikamori; Takashi Yaguchi; Kazutaka Fukushima; Makoto Miyaji; Ken-Ichi Kawai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  67     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-24     Completed Date:  2004-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1580-3     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemistry,  isolation & purification*,  pharmacology
Ascomycota / chemistry*
Aspergillus fumigatus / drug effects
Candida albicans / drug effects
Cryptococcus neoformans / drug effects
Lovastatin / analogs & derivatives*,  chemistry,  pharmacology
Molecular Conformation
Molecular Structure
Naphthalenes / chemistry,  isolation & purification*,  pharmacology
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Naphthalenes; 0/eujavanoic acid A; 0/eujavanoic acid B; 73573-88-3/compactin; 75330-75-5/Lovastatin; 91-17-8/decalin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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