Document Detail

New data about the effects of oral physiological magnesium supplementation on several cardiovascular risk factors (lipids and blood pressure).
MedLine Citation:
PMID:  8155487     Owner:  NLM     Status:  MEDLINE    
In the present study the effect of oral physiological magnesium supplementation on atherogenic risk factors such as serum lipids and blood pressure was examined. Sixty-nine patients with hyperlipidaemia of Frederickson types IV and IIb were investigated with regard to renal function, blood pressure, serum cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol, and plasma and erythrocytic magnesium concentrations. All patients were on cholesterol-poor (< 90 mg cholesterol/d) and energy-restricted diet (< 1200 kcal/d). Thirty-seven patients received 500 mg magnesium (oral) daily as a supplement. All measurements were performed before and four weeks after starting treatment. The results of our study show that oral physiological magnesium supplementation in addition to the usual dietary measures can be beneficial with regard to serum triglycerides (values, means +/- SD, decreased from 198.17 +/- 47.01 to 163.20 +/- 40.55 mg/dl, P < 0.05), but exerts no positive effect on blood pressure or serum cholesterol. Furthermore, erythrocyte magnesium concentration increased significantly during oral physiological magnesium supplementation (values, means +/- SD, increased from 1.72 +/- 0.22 to 1.91 +/- 0.18 mmol/litre, P < 0.05), whereas plasma magnesium concentrations did not change significantly.
K Kisters; C Spieker; M Tepel; W Zidek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnesium research : official organ of the International Society for the Development of Research on Magnesium     Volume:  6     ISSN:  0953-1424     ISO Abbreviation:  Magnes Res     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8900948     Medline TA:  Magnes Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-60     Citation Subset:  IM    
Medizinische Universitäts Poliklinik, Münster, Germany.
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MeSH Terms
Blood Pressure / drug effects*
Cardiovascular Diseases / etiology,  prevention & control*
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Hyperlipidemias / diet therapy,  drug therapy
Lipids / blood*
Magnesium / pharmacology*
Middle Aged
Risk Factors
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol; 7439-95-4/Magnesium

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