Document Detail


New cyclomyrsinol diterpenes from Euphorbia aellenii with their immunomodulatory effects.
MedLine Citation:
PMID:  23281657     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chloroform-acetone extract of the aerial parts of Euphorbia aellenii Rech. f. (Euphorbiaceae) was investigated for its diterpenoidal constituents. This led to the isolation of two new and one known cyclomyrsinol-type diterpenes 1-3. The structures were elucidated on the basis of 1D and 2D (1)H and (13)C NMR techniques, and in vitro immunomodulatory activity was evaluated by standard proliferation of human peripheral blood lymphocytes. Results showed that all the three compounds were found to inhibit lymphocyte proliferation significantly (p < 0.05) at 50 μg/ml concentration. Among them, compound 2 showed more activity against phytohemagglutinin-activated T-cell proliferation with an IC(50) of 40.4 ± 9.35 μg/ml.
Authors:
Mustafa Ghanadian; M Iqbal Choudhary; Abdul Majid Ayatollahi; M Ahmad Mesaik; Omer Mohamed Abdalla; Suleiman Afsharypour
Related Documents :
6610477 - Interleukin 1 can replace monocytes for the specific human b-cell response to a particu...
3110177 - Alpha 2hs glycoprotein is chemotactic for mononuclear phagocytes.
20155817 - The role and therapeutic potential of monocytic cells in alzheimer's disease.
7149487 - Enzyme cytochemical studies of the mononuclear phagocytic cells in human uterine fluid.
15234537 - Characterization of connexin 30.3 and 43 in thymocytes.
23733127 - Cell-based therapies for retinal degenerative diseases: a thousand strategies.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  -     ISSN:  1477-2213     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences , Isfahan , Islamic Republic of Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Long-term molecular remission with lenalidomide treatment of relapsed chronic lymphocytic leukemia.
Next Document:  Comparison of the efficacy of ramosetron and ondansetron in the prophylaxis of postoperative vomitin...