Document Detail

New considerations of the oxygen effects in radiation biology.
MedLine Citation:
PMID:  11537295     Owner:  NASA     Status:  MEDLINE    
The original demonstration in the bacterial spore of the multiple actions of oxygen in modifying the responses of cells to ionizing radiation has now been verified in mammalian systems, pointing up the need for separate inquiry into each of the several components if the responses of mammalian cells are to be understood. We have provided physico-chemical explanations for only two of the four (at least) oxygen elements recognized in the spore: the reaction of diatomic oxygen with organic free radicals in dry spores; and an action of the hydroxy radical (OH) in spores at low [O2]. This paper will discuss newly recognized features of the oxygen responses that could reveal the nature of the other components. It will examine modulation of response by oxides of nitrogen, the similarities and differences among them and explanations for them that suggest further experiment, the importance of concentration of additive in determining both quantity and quality of response, and a general model that explains sensitizer action in terms of inhomogeneous chemistry.
E L Powers
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Advances in space research : the official journal of the Committee on Space Research (COSPAR)     Volume:  9     ISSN:  0273-1177     ISO Abbreviation:  Adv Space Res     Publication Date:  1989  
Date Detail:
Created Date:  2000-10-15     Completed Date:  2000-10-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9878935     Medline TA:  Adv Space Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  S    
Zoology Department, University of Texas, Austin 78712, USA.
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MeSH Terms
Cell Physiological Phenomena / drug effects*,  radiation effects
Free Radicals
Hydroxyl Radical
Nitric Oxide / pharmacology*
Nitrous Oxide / pharmacology*
Oxygen / chemistry,  pharmacology*
Radiation, Ionizing*
Radiation-Sensitizing Agents
Spores, Bacterial / drug effects,  radiation effects
Reg. No./Substance:
0/Free Radicals; 0/Radiation-Sensitizing Agents; 10024-97-2/Nitrous Oxide; 10102-43-9/Nitric Oxide; 3352-57-6/Hydroxyl Radical; 7782-44-7/Oxygen

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