Document Detail

New concepts of the management of one-lung ventilation.
MedLine Citation:
PMID:  16547426     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Hypoxemia is considered to be the most important challenge during one-lung ventilation. Recent studies, however, have shown that one-lung ventilation can involve some lung damage and can therefore be per se a cause of hypoxemia. RECENT FINDINGS: It has been shown that some parameters of one-lung ventilation are associated with an increased probability of lung injury. High tidal volumes can trigger an increase in some inflammatory mediators in both experimental and clinical settings. High inspiratory pressures and/or a collapse of alveoli in every respiratory cycle would lead not only to an impairment of oxygenation, but also to a further incidence of 'postpneumonectomy pulmonary edema', the earlier definition of lung injury associated with one-lung ventilation. SUMMARY: Hypoxemia should always be considered as the most important challenge during one-lung ventilation. One should also keep in mind, however, that some ventilatory strategies can even be harmful.
Mert Sentürk
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in anaesthesiology     Volume:  19     ISSN:  0952-7907     ISO Abbreviation:  Curr Opin Anaesthesiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-20     Completed Date:  2006-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8813436     Medline TA:  Curr Opin Anaesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Department of Anesthesiology, Istanbul University, Istanbul Medical Faculty, Turkey.
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MeSH Terms
Air Pressure
Body Fluids / physiology
Lung / physiology
Oxygen / administration & dosage,  blood
Positive-Pressure Respiration
Respiration, Artificial / trends*
Respiratory Distress Syndrome, Adult / physiopathology,  therapy
Thoracic Surgical Procedures*
Tidal Volume
Reg. No./Substance:

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