Document Detail

New concepts in post-infarction ventricular remodeling.
MedLine Citation:
PMID:  14564229     Owner:  NLM     Status:  MEDLINE    
An understanding of the process of left ventricular (LV) remodeling has led to greater knowledge of the pathophysiology of heart failure syndrome. This article examines the relationship between LV remodeling and clinical outcomes of heart failure syndrome from several different perspectives. The studies cited suggest that the post-myocardial infarction process is related to and associated with long-term progression of LV dysfunction, heart failure symptoms, and mortality. It is also demonstrated that drug therapies that slow or reverse the remodeling process appear to have favorable natural history effects in the short term as well as during long-term therapy.
James E Udelson; Richard D Patten; Marvin A Konstam
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  4 Suppl 3     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-17     Completed Date:  2003-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S3-12     Citation Subset:  IM    
Division of Cardiology, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Heart Failure / drug therapy,  physiopathology*
Myocardial Infarction / drug therapy,  physiopathology*
Renin-Angiotensin System / physiology
Sympathetic Nervous System / physiology
Ventricular Dysfunction, Left / physiopathology*
Ventricular Remodeling* / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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