Document Detail


New concepts in the pathogenesis of Sjögren's syndrome.
MedLine Citation:
PMID:  18984407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sjögren's syndrome (SS) is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathologic autoimmune reaction. SS is manifested by xerostemia and keratoconjunctivitis sicca and marked by persistent focal mononuclear cell infiltration within the salivary glands, often accompanied by glandular atrophy and fibrosis. A challenge is to clarify the roles of genetic backgrounds and environmental trigger. Advanced bioanalytic platforms have enabled identification of potential biomarkers with the intent to improve diagnosis, promote development of prognostic tools, and identify processes for therapeutic treatment. Such approaches allow a glimpse at the apparent complexity of SS.
Authors:
Nicolas Delaleu; Malin V Jonsson; Silke Appel; Roland Jonsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Rheumatic diseases clinics of North America     Volume:  34     ISSN:  1558-3163     ISO Abbreviation:  Rheum. Dis. Clin. North Am.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708093     Medline TA:  Rheum Dis Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  833-45, vii     Citation Subset:  IM    
Affiliation:
Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Haukelandsveien 28, Bergen 5021, Norway.
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MeSH Terms
Descriptor/Qualifier:
Autoimmunity
Biological Markers
Humans
Sjogren's Syndrome / etiology*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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