| New concepts in the pathogenesis of Sjögren's syndrome. | |
| | |
MedLine Citation:
|
PMID: 18984407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sjögren's syndrome (SS) is a rheumatic disease in which the salivary and lacrimal glands are the principal targets of a pathologic autoimmune reaction. SS is manifested by xerostemia and keratoconjunctivitis sicca and marked by persistent focal mononuclear cell infiltration within the salivary glands, often accompanied by glandular atrophy and fibrosis. A challenge is to clarify the roles of genetic backgrounds and environmental trigger. Advanced bioanalytic platforms have enabled identification of potential biomarkers with the intent to improve diagnosis, promote development of prognostic tools, and identify processes for therapeutic treatment. Such approaches allow a glimpse at the apparent complexity of SS. |
| | |
Authors:
|
Nicolas Delaleu; Malin V Jonsson; Silke Appel; Roland Jonsson |
Related Documents
:
|
7889697 - Corticosteroid-responsive parkinsonism associated with primary sjögren's syndrome. 1550417 - Mastocytosis and sjögren's syndrome. 1617817 - Ichthyoses and hyperkeratotic disorders. 11858357 - Fibromyalgia in italian patients with primary sjögren's syndrome. 3407857 - Chiari i malformation with quadriplegia and respiratory disturbance in an infant. 7804457 - Guillain-barré syndrome. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Rheumatic diseases clinics of North America Volume: 34 ISSN: 1558-3163 ISO Abbreviation: Rheum. Dis. Clin. North Am. Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-11-05 Completed Date: 2009-01-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8708093 Medline TA: Rheum Dis Clin North Am Country: United States |
Other Details:
|
Languages: eng Pagination: 833-45, vii Citation Subset: IM |
Affiliation:
|
Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Haukelandsveien 28, Bergen 5021, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autoimmunity Biological Markers Humans Sjogren's Syndrome / etiology* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Orthodontics in 3 millennia. Chapter 15: Skeletal anchorage.
Next Document: Genes and Sjögren's syndrome.