Document Detail


New concepts in liver regeneration.
MedLine Citation:
PMID:  21199532     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The unique ability of the liver to regenerate itself has fascinated biologists for years and has made it the prototype for mammalian organ regeneration. Harnessing this process has great potential benefit in the treatment of liver failure and has been the focus of intense research over the past 50 years. Not only will detailed understanding of cell proliferation in response to injury be applicable to other dysfunction of organs, it may also shed light on how cancer develops in a cirrhotic liver, in which there is intense pressure on cells to regenerate. Advances in molecular techniques over the past few decades have led to the identification of many regulatory intermediates, and pushed us onto the verge of an explosive era in regenerative medicine. To date, more than 10 clinical trials have been reported in which augmented regeneration using progenitor cell therapy has been attempted in human patients. This review traces the path that has been taken over the last few decades in the study of liver regeneration, highlights new concepts in the field, and discusses the challenges that still stand between us and clinical therapy.
Authors:
Kimberly J Riehle; Yock Y Dan; Jean S Campbell; Nelson Fausto
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  26 Suppl 1     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  2011-04-18     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation*
Gene Expression Regulation
Hepatectomy
Hepatocytes / pathology,  transplantation
Humans
Liver / pathology*,  surgery
Liver Diseases / pathology*,  surgery
Liver Regeneration* / genetics
Signal Transduction
Stem Cell Niche
Stem Cell Transplantation
Stem Cells / pathology
Grant Support
ID/Acronym/Agency:
CA-127228/CA/NCI NIH HHS; CA-23226/CA/NCI NIH HHS; CA-74131/CA/NCI NIH HHS; R01 CA074131/CA/NCI NIH HHS; R01 CA074131-14/CA/NCI NIH HHS; R01 CA127228/CA/NCI NIH HHS; R01 CA127228-05/CA/NCI NIH HHS; R37 CA023226/CA/NCI NIH HHS; R37 CA023226-37S1/CA/NCI NIH HHS
Comments/Corrections
Erratum In:
J Gastroenterol Hepatol. 2011 Jul;26(7):1218

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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