| New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. | |
| | |
MedLine Citation:
|
PMID: 22901889 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is characterised by altered cellular composition and homoeostasis in the peripheral lung, leading to excessive accumulation of extracellular matrix and, ultimately, loss of lung function. It is the interstitial pneumonia with the worst prognosis--mortality 3-5 years after diagnosis is 50%. During the past decade, researchers have described several novel cellular and molecular mechanisms and signalling pathways implicated in the pathogenesis of idiopathic pulmonary fibrosis, resulting in the identification of new therapeutic targets. These advances will hopefully result in increased survival rates and improved quality of life for patients with this disorder in future. |
| | |
Authors:
|
Isis E Fernandez; Oliver Eickelberg |
Related Documents
:
|
998279 - Some physical properties of the pulmonary arterial bed deduced from pulsatile arterial ... 20043379 - Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling f... 22606559 - Catheter fracture and embolization related to an arm venous port. 20204749 - Targeting task-1 channels as a therapeutic approach. 22852789 - Development of a perfusion chamber assay to study in real time the kinetics of thrombos... 19679679 - Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletio... 978239 - Angiographic study of the growth of intracranial aneurysms. 16603439 - Antibodies against beta2-glycoprotein i complexed with an oxidised lipoprotein relate t... 998279 - Some physical properties of the pulmonary arterial bed deduced from pulsatile arterial ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Lancet Volume: 380 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-08-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
|
Languages: eng Pagination: 680-8 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Comprehensive Pneumology Centre, University Hospital of the Ludwig-Maximilians University Munich, Munich, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cro...
Next Document: Interstitial lung disease in connective tissue disorders.