Document Detail

New canine model of chronic pancreatitis due to chronic ischemia with incomplete pancreatic duct obstruction.
MedLine Citation:
PMID:  3224767     Owner:  NLM     Status:  MEDLINE    
A new experimental model of chronic pancreatitis was produced by a combination of chronic ischemia and incomplete obstruction of the pancreatic duct. Ischemia was induced by ligation and separation of branches flowing into the left pancreatic lobe from the splenic artery. Incomplete ductal obstruction was achieved by ligation and separation of the minor pancreatic duct and placement of a polyethylene tube in the major pancreatic duct. Macroscopic examination at 6 months after model preparation showed that the pancreas was hard, with severe inflammatory change. In the secretin test, the flow rate of pancreatic juice, amylase output and bicarbonate concentration were significantly reduced as compared with the controls. Pancreatography revealed dilatation and meandering of the major pancreatic duct and poor visualization of its secondary and tertiary bifurcations. The histopathological findings consisted of a decrease in the pancreatic parenchyma, replacement of fat, severe inflammatory cell infiltration, extensive fibrosis and tubular complexes. This model most closely resembles human chronic pancreatitis, and is a very useful instrument.
T Tanaka; Y Ichiba; Y Fujii; H Itoh; O Kodama; K Dohi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestion     Volume:  41     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1988  
Date Detail:
Created Date:  1989-04-06     Completed Date:  1989-04-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Department of Surgery, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Chronic Disease
Pancreas / blood supply*
Pancreatic Ducts / pathology
Pancreatitis / etiology*,  pathology

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