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New boys in town - prognostic role of SF3B1, NOTCH1 and other cryptic alterations in CLL and how it works.
MedLine Citation:
PMID:  23343182     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract B-cell chronic lymphocytic leukemia (B-CLL) is one of the most common leukemias of the elderly. To date, although many prognostic factors are known, none are universal or easily accessible, thus allowing for the stratification of patients to slow-go and aggressive course groups. Recent studies identified new recurrent mutations in CLL cells, including mutation of gene encoding one of spliceosome subunits, SF3B1, mutation or rearrangement of NOTCH1, a gene of well-known tumorigenesis association, and disruption of BIRC3, a member of Inhibitors of Apoptosis (IAP) family. This paper presents the current state of the art findings concerning the prognostic significance of these new alterations, as well as the explanation of the mechanisms underlying their biological impact on CLL lymphocytes.
Authors:
Agata A Filip
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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