Document Detail

New aspects on the heredity of open angle glaucoma.
MedLine Citation:
PMID:  525307     Owner:  NLM     Status:  MEDLINE    
Oen angle glaucoma is known to be inherited, but detailed knowledge of the primary genetic factor and its mode of inheritance are lacking. By studying both the glaucomatous and non-glaucomatous members in afflicted pedigrees, it has been established that premorbid goniodysgenesis, inherited in an autosomal dominant mode, plays a decisive role for the eventual development of glaucoma. Goniodysgenesis has been documented not only in infantile congenital glaucoma but also in late congenital glaucoma (often misinterpreted as glaucoma simplex) and in families with pigmentary glaucoma and exfoliation glaucoma. In addition, there is evidence that goniodysgenesis is the morphological prerequisite of the high elevation of the IOP on provocation with topical steroids. The article contains a short survey of the literature and presents three families with intrafamilial variations of open angle glaucoma based on a dominant genetic trait, viz. goniodysgenesis.
T Jerndal; A Lind
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  57     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  826-31     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Genes, Dominant
Glaucoma / congenital,  genetics*
Infant, Newborn
Intraocular Pressure
Middle Aged

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