| New aspects of drug-induced hypersensitivity syndrome. | |
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MedLine Citation:
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PMID: 21342223 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Drug-induced hypersensitivity syndrome (DIHS) is caused by a limited number of specific drugs and is characterized by late onset, infectious mononucleosis-like symptoms, and herpesvirus 6 (HHV-6) reactivation. Recently, the involvement of herpes viruses other than HHV-6, such as Epstein-Barr virus and cytomegalovirus, has been reported. Many approaches have been used to analyze the pathological mechanism, and have revealed new aspects of DIHS. Here, we focused on three key recent findings regarding DIHS: (i) overlap between DIHS and Stevens-Johnson syndrome/toxic epidermal necrolysis; (ii) the relevance of Epstein-Barr virus in the development of infectious mononucleosis-like symptoms of DIHS; and (iii) roles of monomyeloid precursors increased in the blood and plasmacytoid dendritic cells increased in the lesion skin in HHV-6 reactivation. |
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Authors:
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Mikiko Tohyama; Koji Hashimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 38 ISSN: 1346-8138 ISO Abbreviation: J. Dermatol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 222-8 Citation Subset: IM |
Copyright Information:
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© 2011 Japanese Dermatological Association. |
Affiliation:
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Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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