Document Detail


New artificial nerve conduits made with photocrosslinked hyaluronic acid for peripheral nerve regeneration.
MedLine Citation:
PMID:  17502696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For peripheral nerve regeneration, three-dimensional distribution and growth of cells within the porous scaffold are of clinical significance. We demonstrate that cultured rat Schwann cells and neurospheres grow in vitro on new artificial nerve conduits made with photocrosslinked hyaluronic acid (HA). HA tubular conduits have an inner diameter of 1.2 mm with porous nano-structure of 50 microm. After 3 weeks of cultivation, HA conduits remained circular with a round lumen, and construct of cell-conduits maintained the size and shape of the original architecture of the tube. HA itself has the function to facilitate a pathway for cellular and axonal ingrowth during peripheral nerve regeneration. These findings provide the feasibility of using the HA conduits for better cell adhesion and differentiation, leading to axonal regeneration in peripheral nerve reconstruction.
Authors:
Yoshihito Sakai; Yukihiro Matsuyama; Katsuya Takahashi; Tomoya Sato; Tatsuya Hattori; Shojiro Nakashima; Naoki Ishiguro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bio-medical materials and engineering     Volume:  17     ISSN:  0959-2989     ISO Abbreviation:  Biomed Mater Eng     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-15     Completed Date:  2007-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104021     Medline TA:  Biomed Mater Eng     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Affiliation:
Department of Orthopaedics, Nagoya University School of Medicine, Nagoya City, Japan. jsakai@med.nagoya-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemistry,  radiation effects
Cells, Cultured
Equipment Design
Equipment Failure Analysis
Feasibility Studies
Female
Guided Tissue Regeneration / instrumentation*,  methods
Hyaluronic Acid / chemistry*,  radiation effects
Light
Peripheral Nerves / cytology*,  growth & development*
Photochemistry / methods
Rats
Rats, Sprague-Dawley
Schwann Cells / cytology*,  physiology*
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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