Document Detail


New approaches under development: cardiovascular embryology applied to heart disease.
MedLine Citation:
PMID:  23281412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite many innovative advances in cardiology over the past 50 years, heart disease remains a major killer. The steady progress that continues to be made in diagnostics and therapeutics is offset by the cardiovascular consequences of the growing epidemics of obesity and diabetes. Truly innovative approaches on the horizon have been greatly influenced by new insights in cardiovascular development. In particular, research in stem cell biology, the cardiomyocyte lineage, and the interactions of the myocardium and epicardium have opened the door to new approaches for healing the injured heart.
Authors:
Karl Degenhardt; Manvendra K Singh; Jonathan A Epstein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-03-21    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Complications / epidemiology,  metabolism,  pathology,  physiopathology
Heart Diseases / epidemiology,  etiology,  metabolism*,  physiopathology,  therapy*
Humans
Myocardium / metabolism*,  pathology
Obesity / complications,  epidemiology,  metabolism,  physiopathology,  therapy
Pericardium / embryology*,  metabolism*,  pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
K08 HL094763/HL/NHLBI NIH HHS; K08HL094763-02/HL/NHLBI NIH HHS; U01 HL100405/HL/NHLBI NIH HHS; U01 HL100405/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regenerating new heart with stem cells.
Next Document:  Molecular and genetic basis of sudden cardiac death.