| New approaches under development: cardiovascular embryology applied to heart disease. | |
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MedLine Citation:
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PMID: 23281412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite many innovative advances in cardiology over the past 50 years, heart disease remains a major killer. The steady progress that continues to be made in diagnostics and therapeutics is offset by the cardiovascular consequences of the growing epidemics of obesity and diabetes. Truly innovative approaches on the horizon have been greatly influenced by new insights in cardiovascular development. In particular, research in stem cell biology, the cardiomyocyte lineage, and the interactions of the myocardium and epicardium have opened the door to new approaches for healing the injured heart. |
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Authors:
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Karl Degenhardt; Manvendra K Singh; Jonathan A Epstein |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2013-01-02 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 123 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-03-11 Revised Date: 2013-05-24 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 71-4 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Complications / epidemiology, metabolism, pathology, physiopathology Heart Diseases / epidemiology, etiology, metabolism*, physiopathology, therapy* Humans Myocardium / metabolism*, pathology Obesity / complications, epidemiology, metabolism, physiopathology, therapy Pericardium / embryology*, metabolism*, pathology, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL094763/HL/NHLBI NIH HHS; K08HL094763-02/HL/NHLBI NIH HHS; U01 HL100405/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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