Document Detail

New approaches to screening for vascular and cardiac risk.
MedLine Citation:
PMID:  11411760     Owner:  NLM     Status:  MEDLINE    
Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of remodeling in the left ventricle can identify individuals at risk for morbid events. These individuals should be the target for aggressive lifestyle and pharmacologic interventions known to favorably affect the progression of disease. Techniques are now available for screening of asymptomatic individuals to detect early vascular and cardiac abnormalities likely to lead to progression of disease. Pulse wave analysis provides an assessment of small artery elasticity that appears to correlate with endothelial function. Left ventricular structural alterations can be assessed by ultrasound or by circulating levels of brain natriuretic peptide. The usefulness of these early screening techniques to encourage tailored interventions in susceptible individuals needs to be explored in large-scale trials.
J N Cohn
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of hypertension     Volume:  14     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-19     Completed Date:  2001-12-04     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218S-220S     Citation Subset:  IM    
Department of Medicine, University of Minnesota, Minneapolis 55455, USA.
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MeSH Terms
Heart Diseases / etiology*,  prevention & control*
Mass Screening / methods*
Risk Factors
Vascular Diseases / etiology*,  prevention & control*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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