Document Detail


New approaches to male non-hormonal contraception.
MedLine Citation:
PMID:  22995542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A non-hormonal male contraceptive is a contraceptive that does not involve the administration of hormones or hormone blockers. This review will focus on the use of lonidamine derivatives and inhibitors of retinoic acid biosynthesis and function as approaches to male non-hormonal contraception. Two current lonidamine derivatives, adjudin and H2-gamendazole, are in development as male contraceptives. These potent anti-spermatogenic compounds impair the integrity of the apical ectoplasmic specialization, resulting in premature spermiation and infertility. Another approach to male contraceptive development is the inhibition of retinoic acid in the testes, as retinoic acid signaling is necessary for spermatogenesis. The administration of the retinoic acid receptor antagonist BMS-189453 reversibly inhibits spermatogenesis in mice. Similarly, oral dosing of WIN 18,446, which inhibits testicular retinoic acid biosynthesis, effectively contracepts rabbits. Hopefully, one of these approaches to non-hormonal male contraception will prove to be safe and effective in future clinical trials.
Authors:
Jean-Jacques Nya-Ngatchou; John K Amory
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-09-17
Journal Detail:
Title:  Contraception     Volume:  87     ISSN:  1879-0518     ISO Abbreviation:  Contraception     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-08-15     Revised Date:  2014-05-14    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Contraception / methods*
Contraceptive Agents, Male / pharmacology*
Diamines / pharmacology
Humans
Hydrazines / pharmacology*
Indazoles / pharmacology*
Male
Retinoids / pharmacology
Tretinoin / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
T32 DK007247/DK/NIDDK NIH HHS; U01 HD060408/HD/NICHD NIH HHS; U01 HD060488/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide; 0/BMS 189453; 0/Contraceptive Agents, Male; 0/Diamines; 0/Hydrazines; 0/Indazoles; 0/Retinoids; 0/gamendazole; 1477-57-2/N,N'-bis(dichloroacetyl)-1,8-octamethylenediamine; 5688UTC01R/Tretinoin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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