Document Detail


New approaches to hormonal acceleration of fetal lung maturation.
MedLine Citation:
PMID:  3327938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The paper reviews the effects on lung maturation of glucocorticoids in animals and humans and presents relevant recent findings from the author's laboratory. It is now well established that antenatal glucocorticoid treatment reduces the incidence and severity of the respiratory distress syndrome (RDS) in prematurely born infants. The recommended doses of glucocorticoids produce fetal glucocorticoid activity levels similar to those of newborns with RDS or prolonged rupture of the membranes. Extensive follow-up studies have shown that adverse effects on child development are unlikely to occur. It is also evident that a significant number of fetuses do not respond to the treatment, which is of particular consequence in fetuses of less than 28 weeks gestation. These fetuses are less likely to respond to glucocorticoid therapy that fetuses between 28 and 32 weeks gestation and are at a higher risk of developing complications due to their immaturity. In fetal sheep, there is a similar decrease in the efficacy of glucocorticoids on lung maturation with decreasing gestational age. Simultaneous infusion of cortisol, triiodothyronine and prolactin but not of any of these hormones administered singly or in combination of two produced mature lungs in fetal sheep of 125 days gestation. Similar results were obtained with thyrotropin releasing hormone (TRH) and cortisol. It remains to be seen whether the combined administration of glucocorticoids and TRH accelerates lung maturation in human fetuses.
Authors:
J C Schellenberg; G C Liggins
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  15     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-06     Completed Date:  1988-05-06     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  447-52     Citation Subset:  IM    
Affiliation:
Postgraduate School of Obstetrics and Gynecology, National Women's Hospital, Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic and Fetal Development / drug effects
Glucocorticoids / pharmacology,  therapeutic use
Hormones / pharmacology*
Humans
Hydrocortisone / pharmacology
Infant, Newborn
Lung / embryology*
Respiratory Distress Syndrome, Newborn / prevention & control
Sheep
Triiodothyronine / pharmacology
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Hormones; 50-23-7/Hydrocortisone; 6893-02-3/Triiodothyronine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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