Document Detail

New approaches to hepatocellular carcinoma and concomitant esophageal varices prolong survival.
MedLine Citation:
PMID:  2174828     Owner:  NLM     Status:  MEDLINE    
A retrospective study was done on 226 patients with hepatocellular carcinoma and coexisting esophageal varices treated at our institute between 1974 and 1988. The patients were divided into two groups: Group A containing patients treated between 1974 and 1982 (n = 92), and Group B comprising those treated between 1983 and 1988 (n = 134). Surgical treatments were applied to 64 patients (69.6%) and 37 patients (27.6%) in groups A and B, respectively (p less than 0.001). Ninety out of 134 patients (67.2%) in group B were prescribed regional chemotherapy. Forty-nine patients (53.3%) in group A, and 96 (71.6%) in group B had esophageal varices that were about to rupture as indicated endoscopically. Nineteen patients (38.8%) in group A, and 10 (10.4%) in group B were treated surgically (p less than 0.005). The varices in 76 out of 96 patients (79.2%) in group B were treated by endoscopic sclerotherapy. Survival rates during the first 5 years in groups A and B were 28% and 65%, 16% and 43%, 5% and 27%, 4% and 18%, and 4% and 6%, respectively. It would appear that appropriate conservative treatment of the poor surgical candidates will, in general, lead to good clinical results.
T Matsumata; T Kanematsu; K Shirabe; T Sonoda; S Kitano; K Sugimachi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  37     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-01-24     Completed Date:  1991-01-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  489-93     Citation Subset:  IM    
Second Department of Surgery, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
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MeSH Terms
Carcinoma, Hepatocellular / complications,  mortality,  therapy*
Esophageal and Gastric Varices / complications,  therapy*
Liver Neoplasms / complications,  mortality,  therapy*
Middle Aged

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