Document Detail


New approaches to expand hematopoietic stem and progenitor cells.
MedLine Citation:
PMID:  22519359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Hematopoietic stem cells (HSCs) are defined by their capacity to self-renew and to differentiate into all blood cell lineages, and are currently the foundation of HSC transplantation therapy. A variety of methods have recently been explored to find a way to expand hematopoietic stem and progenitor cells (HSCs/PCs) ex vivo in order to improve the efficiency and outcome of HSC transplantation.
AREAS COVERED: Recent studies of HSCs/PCs have led to the development of new ways to detect and purify HSCs/PCs and have also revealed several intrinsic and extrinsic factors that control the molecular signals fundamental to self-renewal and differentiation of HSCs. These findings have provided new approaches for expanding HSCs/PCs ex vivo utilizing protein factors and small-molecule compounds (SMCs) and have also demonstrated promising outcomes in clinical trials.
EXPERT OPINION: Although further technical innovation is still needed, elucidation of the whole picture of signaling pathways critical to HSCs/PCs and manipulation of such pathways by SMCs could establish efficient, cost-effective, riskless and robust methods for ex vivo expansion of HSCs/PCs. With these efforts, more sophisticated HSC transplantation would be possible in the near future.
Authors:
Taito Nishino; Mitsujiro Osawa; Atsushi Iwama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-23
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  12     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-09-06     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  743-56     Citation Subset:  IM    
Affiliation:
Nissan Chemical Industries, Research Planning Department, 3-7-1 Kanda-nishiki-cho, Chiyoda-ku, Tokyo 101-0054, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / metabolism
Cell Culture Techniques*
Cell Differentiation* / drug effects
Cell Proliferation* / drug effects
Cell Separation / methods*
Cells, Cultured
Hematopoietic Stem Cell Transplantation*
Hematopoietic Stem Cells / drug effects,  metabolism,  physiology*
Humans
Signal Transduction
Chemical
Reg. No./Substance:
0/Biological Markers

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