Document Detail

New approaches to the diagnosis of preterm labor.
MedLine Citation:
PMID:  9914626     Owner:  NLM     Status:  MEDLINE    
There is a pressing need to develop accurate methods of diagnosing true preterm labor because of the availability of potent tocolytic drugs and the known beneficial effects of antenatal glucocorticoid administration on neonatal outcomes of premature infants. Maternal plasma corticotropin-releasing hormone concentrations are elevated in women with threatened preterm labor between 28 and 36 weeks' gestation who give birth within 24 hours. In addition, the ratio of cortisol to corticosteroid binding capacity is elevated in the plasma of women who give birth within 24 hours. These data support the design and conduct of a prospective clinical trial to determine the positive and negative predictive values of these markers for preterm birth in women with symptoms.
A D Bocking; J R Challis; C Korebrits
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  180     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-22     Completed Date:  1999-02-22     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S247-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, University of Western Ontario, Lawson Research Institute, St. Joseph's Health Centre, London, Canada.
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MeSH Terms
Adrenal Cortex Hormones / metabolism
Carrier Proteins / blood
Corticotropin-Releasing Hormone / blood
Delivery, Obstetric
Hydrocortisone / blood
Obstetric Labor, Premature / blood,  diagnosis*
Obstetrics / methods*
Pregnancy Trimester, Third / blood
Time Factors
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Carrier Proteins; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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