Document Detail


New approaches to detect cortisol administration in the horse.
MedLine Citation:
PMID:  10454084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cortisol threshold concentration of 1.0 microg/ml in horse urine adopted by the International Federation of the racing Authorities in 1994 is specific. However, an increase in the sensitivity for the detection of cortisol administration would be helpful. Previous studies have shown that 20beta-dihydrocortisol concentration in urine would be a good indicator of cortisol administration. The purpose of the present work was to estimate the population parameters and the critical values of 20beta-dihydrocortisol and 20beta-dihydrocortisone concentration in urine compared with that of cortisol. Using the same probability (1.1 x 10(-4)) which was used for the establishment of the official cortisol threshold, the critical values of 5000 ng/ml for 20beta-dihydrocortisol and 350 ng/ml for 20beta-dihydrocortisone were obtained. Considering these 2 critical values for 20beta-dihydrocortisol and 20beta-dihydrocortisone, the time during which a horse could be declared positive is significantly increased.
Authors:
M A Popot; E Lacabaratz; P Garcia; V Laroute; Y Bonnaire; P L Toutain; D A Cowan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Equine veterinary journal     Volume:  31     ISSN:  0425-1644     ISO Abbreviation:  Equine Vet. J.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-11-30     Completed Date:  1999-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  IM    
Affiliation:
L.A.B., Chatenay Malabry, France.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Analysis of Variance
Animals
Chromatography, High Pressure Liquid / veterinary
Cortisone / analogs & derivatives*,  urine
Doping in Sports*
Female
Horses / urine*
Hydrocortisone / administration & dosage,  analogs & derivatives*,  pharmacokinetics*,  urine
Injections, Intravenous / veterinary
Male
Mass Spectrometry / veterinary
Physical Conditioning, Animal
Reference Values
Sensitivity and Specificity
Chemical
Reg. No./Substance:
2899-95-8/20-hydroxycortisol; 3615-87-0/4-pregnene-17 alpha,20 beta,21-triol-3,11-dione; 50-23-7/Hydrocortisone; 53-06-5/Cortisone
Comments/Corrections
Comment In:
Equine Vet J. 1999 Jul;31(4):266-7   [PMID:  10454081 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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