| New approaches for persistent pulmonary hypertension of newborn. | |
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MedLine Citation:
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PMID: 15325540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The management of PPHN entered a new era with the development of inhaled NO therapy for the relief of pulmonary hypertension. The wider application of INO therapy and improved ventilation strategies led to a decrease in the need for invasive life-sustaining therapies such as ECMO. The remarkable advances in the understanding and treatment of PPHN were made possible by the extensive investigations in the laboratory using animal models. Further decreases in morbidity and mortality are possible with specific strategies targeted to correct the alterations in NO and prostacyclin biology and strategies to reduce lung injury. Further research is needed to understand the basis for the biologic susceptibility of some infants to environmental insults such as intra-uterine stressor exposure to NSAIDs in utero. |
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Authors:
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G Ganesh Konduri |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Clinics in perinatology Volume: 31 ISSN: 0095-5108 ISO Abbreviation: Clin Perinatol Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2005-02-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 591-611 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Medical College of Wisconsin and Children's Research Institute of Children's Hospital of Wisconsin, MS 213 A, Milwaukee, WI 53226, USA. gkonduri@mcw.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Humans Infant, Newborn Nitric Oxide / administration & dosage* Persistent Fetal Circulation Syndrome / complications, drug therapy*, physiopathology Prognosis |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL57268/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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