Document Detail

New approaches for persistent pulmonary hypertension of newborn.
MedLine Citation:
PMID:  15325540     Owner:  NLM     Status:  MEDLINE    
The management of PPHN entered a new era with the development of inhaled NO therapy for the relief of pulmonary hypertension. The wider application of INO therapy and improved ventilation strategies led to a decrease in the need for invasive life-sustaining therapies such as ECMO. The remarkable advances in the understanding and treatment of PPHN were made possible by the extensive investigations in the laboratory using animal models. Further decreases in morbidity and mortality are possible with specific strategies targeted to correct the alterations in NO and prostacyclin biology and strategies to reduce lung injury. Further research is needed to understand the basis for the biologic susceptibility of some infants to environmental insults such as intra-uterine stressor exposure to NSAIDs in utero.
G Ganesh Konduri
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  31     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2005-02-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  591-611     Citation Subset:  IM    
Division of Neonatology, Medical College of Wisconsin and Children's Research Institute of Children's Hospital of Wisconsin, MS 213 A, Milwaukee, WI 53226, USA.
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MeSH Terms
Administration, Inhalation
Infant, Newborn
Nitric Oxide / administration & dosage*
Persistent Fetal Circulation Syndrome / complications,  drug therapy*,  physiopathology
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide

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