Document Detail

New approach to cystic fibrosis diagnosis by use of an improved sweat-induction/collection system and osmometry.
MedLine Citation:
PMID:  7471385     Owner:  NLM     Status:  MEDLINE    
A comprehensive equipment system is described that induces, collects, and analyzes sweat as a diagnostic procedure for cystic fibrosis. The safety and convenience of the iontophoretic induction phase have been improved by specially designed circuitry and electrodes. The problem of potentially serious error as a result of condensation within sweat-collection cups has been eliminated by use of a thermostatically controlled heated cup. The osmolality of the collected sweat is measured with a vapor-pressure osmometer. Data are presented to support the validity of osmolality as an alternative to electrolyte assay or electrical conductivity measurement and normal and abnormal ranges are provided. The complete system was tested in a pediatric hospital and data are presented to illustrate the relative advantages of the system with respect to safety, convenience, diagnostic reliability, and decreased potential for human error.
H L Webster; W K Barlow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  27     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-13     Completed Date:  1981-05-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-7     Citation Subset:  IM    
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MeSH Terms
Chlorides / analysis
Cystic Fibrosis / diagnosis*
Iontophoresis / instrumentation*
Osmolar Concentration
Pilocarpine / pharmacology
Specimen Handling* / instrumentation
Sweat / analysis*,  secretion
Sweat Glands / drug effects
Reg. No./Substance:
0/Chlorides; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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