| New approach to cystic fibrosis diagnosis by use of an improved sweat-induction/collection system and osmometry. | |
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MedLine Citation:
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PMID: 7471385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comprehensive equipment system is described that induces, collects, and analyzes sweat as a diagnostic procedure for cystic fibrosis. The safety and convenience of the iontophoretic induction phase have been improved by specially designed circuitry and electrodes. The problem of potentially serious error as a result of condensation within sweat-collection cups has been eliminated by use of a thermostatically controlled heated cup. The osmolality of the collected sweat is measured with a vapor-pressure osmometer. Data are presented to support the validity of osmolality as an alternative to electrolyte assay or electrical conductivity measurement and normal and abnormal ranges are provided. The complete system was tested in a pediatric hospital and data are presented to illustrate the relative advantages of the system with respect to safety, convenience, diagnostic reliability, and decreased potential for human error. |
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Authors:
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H L Webster; W K Barlow |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical chemistry Volume: 27 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-05-13 Completed Date: 1981-05-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 385-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chlorides
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analysis Cystic Fibrosis / diagnosis* Humans Iontophoresis / instrumentation* Osmolar Concentration Pilocarpine / pharmacology Specimen Handling* / instrumentation Sweat / analysis*, secretion Sweat Glands / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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