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New antimicrobial compounds from a marine-derived Bacillus sp.
MedLine Citation:
PMID:  23211933     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the course of our ongoing research for antimicrobial agents, we isolated five new compounds, three 24-membered macrolactones, macrolactins X-Z (1-3) and two hydroxy unsaturated fatty acids, linieodolides A (5) and B (6), together with a known metabolite, macrolactinic acid (4), from the culture broth of a marine Bacillus sp. The structures of these metabolites were determined on the basis of their spectroscopic data interpretation. Their absolute configurations were addressed by modified Mosher's method and literature data review. Compounds 1-6 showed moderate to potent inhibitory activities (8∼128 μg ml(-1)) against selected pathogenic microorganisms.The Journal of Antibiotics advance online publication, 5 December 2012; doi:10.1038/ja.2012.102.
Authors:
Mohamad Abdul Mojid Mondol; Fakir Shahidullah Tareq; Ji Hye Kim; Min Ah Lee; Hyi-Seung Lee; Jong Seok Lee; Yeon-Ju Lee; Hee Jae Shin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-05
Journal Detail:
Title:  The Journal of antibiotics     Volume:  -     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
School of Science and Technology, Bangladesh Open University, Gazipur, Bangladesh.
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