Document Detail

New analogues of the anticancer E7070: synthesis and pharmacology.
MedLine Citation:
PMID:  12943191     Owner:  NLM     Status:  MEDLINE    
Cell cycle control in the G1 phase has attracted considerable attention in recent cancer research, because many of the important proteins involved in G1 progression or G1/S transition have been found to play a crucial role in proliferation, differentiation, transformation, and programmed cell death (apoptosis). E7070 is a novel antitumor sulfonamide, with a unique mode of action that affects G1 progression of the cell cycle. A series of compounds containing an N-[1-(3,4,5-trimethoxybenzyl)-1H-indol-5-yl]benzene sulfonamide, analogues of E7070, was synthesized and evaluated as potential antitumor agents. Cell cycle analysis with PC3 human prostate cancer cells revealed a cellular accumulation in the G1 phase.
G Laconde; N Pommery; P Depreux; P Berthelot; J P Hénichart
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  18     ISSN:  1475-6366     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-08-28     Completed Date:  2004-01-30     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, 3 rue du Professeur Laguesse, B.P. 83, 59006 Lille, France.
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MeSH Terms
Antineoplastic Agents* / chemical synthesis,  chemistry,  pharmacology
Cell Division / drug effects
Drug Screening Assays, Antitumor
G1 Phase / drug effects*
Inhibitory Concentration 50
Prostatic Neoplasms / pathology
Structure-Activity Relationship
Sulfonamides* / chemical synthesis,  chemistry,  pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide; 0/Sulfonamides

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