Document Detail


New agents for colorectal cancer.
MedLine Citation:
PMID:  19764156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The past 5 years have seen significant developments in the treatment of colorectal cancer (CRC). New chemotherapy agents with activity in CRC have demonstrated an improvement in survival for patients with advanced CRC. Studies now are focusing on combinations and sequences of chemotherapy agents to prolong survival in second- and even third-line therapies. Oral agents have been developed and are being studied in combination chemotherapy regimens. Development of oral combinations should maintain a survival advantage with the added benefit of convenience for the patient. Drugs designed to act on specific cellular protein targets have also shown activity and are being explored further. Researchers continue to pursue immunotherapy and vaccine therapy. Studies are now focusing on how best to use the available agents. These new agents and new combinations of agents and of approaches have led and should continue to lead to improved outcomes in the treatment of patients with CRC.
Authors:
Mary E Mulcahy; Al B Benson
Related Documents :
7537896 - Palliative chemotherapy in advanced bladder cancer.
8472436 - Chemotherapy for soft-tissue sarcomas.
24894126 - Diagnostic evaluation and short-term outcome as indicators of long-term prognosis in ho...
25012266 - Clinical and pathological response to neoadjuvant chemotherapy based on primary tumor r...
19279046 - Recurrence of endometriosis and its control.
23042716 - Pseudoprogression after high-dose busulfan-thiotepa with autologous stem cell transplan...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the National Comprehensive Cancer Network : JNCCN     Volume:  1     ISSN:  1540-1405     ISO Abbreviation:  J Natl Compr Canc Netw     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101162515     Medline TA:  J Natl Compr Canc Netw     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-36     Citation Subset:  IM    
Affiliation:
Division of Hematology and Oncology/Department of Medicine, Feinberg School of Medicine, Northwestern University Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60611, USA. m-mulcahy@northwestern.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / therapeutic use*
Clinical Trials as Topic
Colorectal Neoplasms / drug therapy*
Humans
Immunotherapy
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Controversies in the surgical management of gastric cancer.
Next Document:  The genetics of hereditary non-polyposis colorectal cancer.