| New advances in the treatment of infertility in women with ovarian failure. | |
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MedLine Citation:
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PMID: 8329653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ovarian failure is heterogeneous in etiology and may occur at various points in a woman's life. As such, it may interfere with fertility. Clinical presentation ranges from complete cessation of menses to oligomenorrhea to the continuation of menses with elevated gonadotropins. Various therapies have been used in an attempt to induce fertility, including sex steroids and gonadotropin-releasing hormone agonists to suppress circulating gonadotropin alone or in combination with estrogen or gonadotropin-releasing hormone agonists to induce ovulation. Corticosteroids are also used to overcome autoimmunity. Randomized therapeutic trials are rare and fail to demonstrate any significant improvement in ovulation and pregnancy rates. Donor oocytes have demonstrated high success rates and have proven to be useful in patients with both premature ovarian failure and natural menopause. Pregnancies have been initiated and maintained in women through 60 years of age. Thus, for those accepting of the technique, oocyte donation appears to be the treatment of choice for hypergonadotropic hypogonadism. |
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Authors:
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R S Morris; M V Sauer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in obstetrics & gynecology Volume: 5 ISSN: 1040-872X ISO Abbreviation: Curr. Opin. Obstet. Gynecol. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-08-19 Completed Date: 1993-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9007264 Medline TA: Curr Opin Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 368-77 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Biopsy Clomiphene / therapeutic use Embryo Transfer Female Fertilization in Vitro Gonadal Steroid Hormones / therapeutic use Gonadotropins / blood Humans Infertility, Female / etiology, therapy* Menopause Menotropins / therapeutic use Oocytes / transplantation Ovarian Failure, Premature / blood, complications, diagnosis, therapy* Ovulation Induction / methods Pregnancy Pregnancy Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Gonadal Steroid Hormones; 0/Gonadotropins; 61489-71-2/Menotropins; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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