Document Detail

New advances in the treatment of infertility in women with ovarian failure.
MedLine Citation:
PMID:  8329653     Owner:  NLM     Status:  MEDLINE    
Ovarian failure is heterogeneous in etiology and may occur at various points in a woman's life. As such, it may interfere with fertility. Clinical presentation ranges from complete cessation of menses to oligomenorrhea to the continuation of menses with elevated gonadotropins. Various therapies have been used in an attempt to induce fertility, including sex steroids and gonadotropin-releasing hormone agonists to suppress circulating gonadotropin alone or in combination with estrogen or gonadotropin-releasing hormone agonists to induce ovulation. Corticosteroids are also used to overcome autoimmunity. Randomized therapeutic trials are rare and fail to demonstrate any significant improvement in ovulation and pregnancy rates. Donor oocytes have demonstrated high success rates and have proven to be useful in patients with both premature ovarian failure and natural menopause. Pregnancies have been initiated and maintained in women through 60 years of age. Thus, for those accepting of the technique, oocyte donation appears to be the treatment of choice for hypergonadotropic hypogonadism.
R S Morris; M V Sauer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  5     ISSN:  1040-872X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  368-77     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles 90033.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Clomiphene / therapeutic use
Embryo Transfer
Fertilization in Vitro
Gonadal Steroid Hormones / therapeutic use
Gonadotropins / blood
Infertility, Female / etiology,  therapy*
Menotropins / therapeutic use
Oocytes / transplantation
Ovarian Failure, Premature / blood,  complications,  diagnosis,  therapy*
Ovulation Induction / methods
Pregnancy Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Gonadal Steroid Hormones; 0/Gonadotropins; 61489-71-2/Menotropins; 911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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