Document Detail


New advances in the chemistry of methoxylated lipids.
MedLine Citation:
PMID:  12169299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methoxylated lipids have been reviewed emphasizing the alkylglycerol ethers and fatty acids bearing the methoxy group in the alkyl chain. The literature on methoxylated lipids and their derivatives has been divided into four main groups, namely 2-methoxylated alkyl glycerols, omega-methoxylated fatty acids, mid-chain methoxylated fatty acids, and alpha-methoxylated fatty acids. The natural occurrence, biological activity, and synthesis of this interesting group of lipids are discussed. Most of these compounds have been isolated from either bacterial or marine sources, but others are mainly of synthetic origin. Among the interesting biological activities displayed by these compounds the most important are antibacterial, antifungal, antitumor, and antiviral.
Authors:
N M Carballeira
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Progress in lipid research     Volume:  41     ISSN:  0163-7827     ISO Abbreviation:  Prog. Lipid Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-08-09     Completed Date:  2002-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7900832     Medline TA:  Prog Lipid Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-56     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Puerto Rico, PO Box 23346, San Juan, Puerto Rico 00931-3346. ncarball@upracd.upr.clu.edu
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MeSH Terms
Descriptor/Qualifier:
Algae, Red / metabolism
Animals
Anti-Bacterial Agents
Antifungal Agents
Antimetabolites*
Antineoplastic Agents
Bacteria / metabolism
Fatty Acids / chemical synthesis,  chemistry,  metabolism
Glycerol / chemical synthesis,  chemistry,  metabolism
Lipid Metabolism
Lipids / chemical synthesis,  chemistry*
Porifera / metabolism
Grant Support
ID/Acronym/Agency:
S06GM08102/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Antimetabolites; 0/Antineoplastic Agents; 0/Fatty Acids; 0/Lipids; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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