Document Detail

New and active role of the interstitium in control of interstitial fluid pressure: potential therapeutic consequences.
MedLine Citation:
PMID:  12631039     Owner:  NLM     Status:  MEDLINE    
Here we present recent data indicating that the present view of the interstitium as a passive fluid reservoir has to be revised. The connective tissue cells and extracellular matrix have a role in the control of P(if) and a fundamental role in the rapid development of edema in burns and in the initial swelling in inflammation by generating a lowering of interstitial fluid pressure. In this process, the beta1-integrin system seems to provide a common pathway by which the cells can lower as well as raise P(if). Inflammatory swelling can be reversed by endo- and exogenous substances, thereby suggesting that the connective tissue can serve as a novel target for pharmacological intervention. Furthermore, the new knowledge in interstitial physiology on means to reduce interstitial fluid pressure may be of importance for drug delivery into solid tumors, where a high P(if) limits the uptake of therapeutic agents.
H Wiig; K Rubin; R K Reed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  47     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-12     Completed Date:  2003-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  111-21     Citation Subset:  IM    
Copyright Information:
Copyright Acta Anaesthesiologica Scandinavica 47 (2003)
Department of Physiology and Locus for Circulatory Research, University of Bergen, Bergen, Norway.
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MeSH Terms
Antigens, CD29 / physiology
Antineoplastic Agents / administration & dosage,  therapeutic use
Capillaries / physiology
Edema / physiopathology
Extracellular Space / drug effects,  physiology*
Inflammation / physiopathology
Reg. No./Substance:
0/Antigens, CD29; 0/Antineoplastic Agents

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