Document Detail


New acquisitions in Helicobacter pylori characteristics.
MedLine Citation:
PMID:  10077748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The protection of Helicobacter pylori from the gastric acid exerted by urease is based on an increase of the bacterial periplasmic pH and membrane potential. Ammonia generated from urea induces apoptosis of gastric cells in vitro, and inhibits gastric somatostatin release in animals, which could have consequences on the physiology of digestion in general. The type s1/m1 structure of the vacA gene is associated with the production of high levels of cytotoxin. Strains with m2 region type, formerly considered devoid of toxic activity, are fully toxic when assayed with cell lines other than HeLa cells, which possibly lack receptors for m2 VacA type. The enhanced gastric mucosa damage associated with infection by cytotoxic organisms could be explained by the varying of effects exerted by VacA on target cells: extracellular secretion of acidic hydrolases, cytoskeletal alterations, actin rearrangement, reduction of epidermal growth factor binding to its receptor, inhibition of the stimulation of CD4+ T cells proliferation induced by the antigen presenting cells. Organisms that possess the pathogenicity island cag (cag+) induce an increased inflammation and transduction of signals to the host cells; however, they reduce the apoptosis of colonised cells. The results of an investigation on the possible influence of a variable cagA status on the extension of apoptosis have indicated that this kind of programmed death is disengaged from the possession of cagA by Helicobacter pylori organisms colonising the same gastric areas. It is likely that the whole pathogenic potential of cag+ organisms is far from being completely explored, as suggested by the recent finding that the expression of a bacterial adhesin (called BabA) involved in binding to the blood group antigen Lewis b is associated with the presence of cag.
Authors:
N Figura; C Vindigni; L Presenti; A Carducci
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Italian journal of gastroenterology and hepatology     Volume:  30 Suppl 3     ISSN:  1125-8055     ISO Abbreviation:  Ital J Gastroenterol Hepatol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-04-26     Completed Date:  1999-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9711056     Medline TA:  Ital J Gastroenterol Hepatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  S254-8     Citation Subset:  IM    
Affiliation:
Institute of Internal Medicine, University of Siena, Italy. figura@unisi.it
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Bacterial*
Apoptosis
Bacterial Proteins / biosynthesis
Bacterial Toxins / biosynthesis
CD4-Positive T-Lymphocytes / immunology
Cell Division
DNA, Bacterial / analysis
Gastric Mucosa / immunology,  microbiology,  pathology
Genome, Bacterial
Helicobacter Infections / immunology,  microbiology*,  pathology
Helicobacter pylori* / genetics,  immunology,  pathogenicity
Humans
Lymphocyte Activation
Peptic Ulcer / immunology,  microbiology,  pathology
Stomach Neoplasms / immunology,  microbiology,  pathology
Urease / metabolism
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Bacterial Proteins; 0/Bacterial Toxins; 0/DNA, Bacterial; 0/VacA protein, Helicobacter pylori; 0/cagA protein, Helicobacter pylori; EC 3.5.1.5/Urease

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