Document Detail


New acetylenes isolated from the bark of Heisteria acuminata.
MedLine Citation:
PMID:  9584394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five new linear acetylenic compounds, namely, pentadeca-6,8,10-triynoic acid (1), octadeca-8,10,12-triynoic acid (2), trans-pentadec-10-en-6,8-diynoic acid (3), cis-hexadec-11-en-7,9-diynoic acid (4), and cis-octadec-12-en-7,9-diynoic acid (5), were isolated from the bark of Heisteria acuminata by bioassay-guided fractionation, using cyclooxygenase (COX) and 5-lipoxygenase (5-LO) assays as models for antiinflammatory activity. The structures of compounds 1-5 were established by NMR, MS, IR, and Raman spectroscopy. These isolated compounds were found to be potent inhibitors of COX. Compounds 4 and 5 were the most potent inhibitors of 5-LO, whereas the other compounds only showed a weak inhibition at the same concentration.
Authors:
C M Kraus; A Neszmélyi; S Holly; B Wiedemann; A Nenninger; K B Torssell; L Bohlin; H Wagner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  61     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-11     Completed Date:  1998-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Biology, University of Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acetylene / analogs & derivatives*,  isolation & purification*,  pharmacology
Anti-Inflammatory Agents / isolation & purification*,  pharmacology
Cyclooxygenase Inhibitors / isolation & purification,  pharmacology
Ecuador
Lipoxygenase Inhibitors / isolation & purification,  pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Plant Epidermis / chemistry*
Plant Extracts / chemistry,  pharmacology
Plants, Medicinal / chemistry*
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Steroids
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cyclooxygenase Inhibitors; 0/Lipoxygenase Inhibitors; 0/Plant Extracts; 0/Steroids; 74-86-2/Acetylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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