Document Detail

The New York High-Risk Project: anhedonia, attentional deviance, and psychopathology.
MedLine Citation:
PMID:  8451608     Owner:  NLM     Status:  MEDLINE    
In the New York High-Risk Project (NYHRP) we followed subjects at risk for schizophrenic or affective disorders and low-risk controls from childhood to adulthood, with the goal of identifying early predictors of later schizophrenia-related psychopathology. In this article, we focus on two potential predictors: the Physical Anhedonia Scale administered in adolescence and the Attention Deviance Index obtained in childhood. Subjects of this report are 161 members of the NYHRP's first sample (sample A), who had scores on both attention and anhedonia and had followup clinical assessments in adulthood. We used a path analysis model and several separate regression analyses to examine the relationships of the parent diagnostic groups, attentional dysfunction, and anhedonia to each other and to each of three psychopathological outcomes: schizophrenia and schizophrenia-related psychoses, major affective disorder, and social isolation in nonpsychotic subjects. Subject groups did not differ in anhedonia scores but did differ in childhood attentional dysfunction, psychosis, and social isolation, all of which are more common in subjects at risk for schizophrenia. In these subjects at risk for schizophrenia, but not in the other two groups of subjects, childhood attentional dysfunction is related to anhedonia, social isolation, and possibly nonparanoid psychosis. Anhedonia is associated with social isolation and with psychosis in females. Several other gender effects are also noted.
L Erlenmeyer-Kimling; B A Cornblatt; D Rock; S Roberts; M Bell; A West
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  19     ISSN:  0586-7614     ISO Abbreviation:  Schizophr Bull     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-12     Completed Date:  1993-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-53     Citation Subset:  IM    
Dept. of Medical Genetics, New York State Psychiatric Institute, NY 10032.
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MeSH Terms
Affective Symptoms / diagnosis,  genetics*,  psychology
Bipolar Disorder / diagnosis,  genetics,  psychology
Follow-Up Studies
New York City
Psychiatric Status Rating Scales
Risk Factors
Schizoid Personality Disorder / diagnosis,  genetics,  psychology
Schizophrenia / diagnosis,  genetics*
Schizophrenic Psychology*
Schizotypal Personality Disorder / diagnosis,  genetics*,  psychology
Social Isolation
Urban Population*
Grant Support

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