| New York Heart Association functional class predicts exercise parameters in the current era. | |
| | |
MedLine Citation:
|
PMID: 19782785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The New York Heart Association (NYHA) functional class is a subjective estimate of a patient's functional ability based on symptoms that do not always correlate with the objective estimate of functional capacity, peak oxygen consumption (peak V(O2)). In addition, relationships between these 2 measurements have not been examined in the current medical era when patients are using beta-blockers, aldosterone antagonists, and cardiac resynchronization therapy (CRT). Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship. METHODS: One thousand seven hundred fifty-eight patients underwent a symptom-limited metabolic stress test and stopped exercise due to dyspnea or fatigue. The relationship between NYHA functional class and peak V(O2) was examined. In addition, the effects of beta-blockers, aldosterone antagonists, and CRT therapy on these relationships were compared. RESULTS: The NYHA II patients have a significantly higher peak Vo(2) (16.1 +/- 4.6 vs 13.0 +/- 4.2 mL/kg per minute), a lower ventilation (Ve)/V(CO2) slope (32.8 +/- 7.7 vs 36.8 +/- 10.4), and a longer duration of exercise (11.0 +/- 3.9 vs 8.0 +/- 3.4 minutes) than NYHA III/IV patients. Within each functional class, there was no difference in any of the exercise parameters between patients on or off of beta-blockers, aldosterone antagonists, or CRT therapy. Finally, with increasing age, a significant difference in peak Vo(2), Ve/V(CO2) slope, and exercise time was found. CONCLUSION: For patients being treated with current medical therapy, there still is a difference in true functional capacity between NYHA functional class II and III/IV patients. However, within each NYHA functional class, the presence or absence or contemporary heart failure therapies does not alter exercise parameters. |
| | |
Authors:
|
Stuart D Russell; Matthew A Saval; Jennifer L Robbins; Myrvin H Ellestad; Stephen S Gottlieb; Eileen M Handberg; Yi Zhou; Bleakley Chandler; |
Related Documents
:
|
17628515 - Exercise training restores aerobic capacity and energy transfer systems in heart failur... 1464335 - Food in chronic heart failure: improvement in central haemodynamics but deleterious eff... 3518725 - Positive inotropic effects of ibopamine in patients with congestive heart failure. a mu... 14871005 - The implications of physical activity in patients with chronic heart failure. 1910345 - Cardiorespiratory and lactate responses to a 1-hour submaximal running at the lactate t... 14506725 - Progressive exercise intolerance associated with a new muscle-restricted nonsense mutat... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: American heart journal Volume: 158 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-28 Completed Date: 2009-10-29 Revised Date: 2012-05-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
|
Languages: eng Pagination: S24-30 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA. srusse14@jhmi.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00047437 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
therapeutic use Aldosterone Antagonists / therapeutic use Cardiac Pacing, Artificial / methods Data Collection / statistics & numerical data Electrocardiography Exercise Test / classification, statistics & numerical data* Exercise Tolerance Female Heart / physiopathology Heart Failure / diagnosis, physiopathology*, therapy Humans Male Middle Aged Oxygen Consumption / physiology* Pulmonary Ventilation / physiology Severity of Illness Index Treatment Outcome Ventricular Dysfunction, Left / physiopathology, therapy |
| Grant Support | |
ID/Acronym/Agency:
|
5U01HL063747/HL/NHLBI NIH HHS; 5U01HL064250/HL/NHLBI NIH HHS; 5U01HL064257/HL/NHLBI NIH HHS; 5U01HL064264/HL/NHLBI NIH HHS; 5U01HL064265/HL/NHLBI NIH HHS; 5U01HL066482/HL/NHLBI NIH HHS; 5U01HL066491/HL/NHLBI NIH HHS; 5U01HL066494/HL/NHLBI NIH HHS; 5U01HL066497/HL/NHLBI NIH HHS; 5U01HL066501/HL/NHLBI NIH HHS; 5U01HL068973/HL/NHLBI NIH HHS; 5U01HL068980/HL/NHLBI NIH HHS; P60AG10484/AG/NIA NIH HHS; R37 AG018915/AG/NIA NIH HHS; R37AG18915/AG/NIA NIH HHS; U01 HL063747-01A2/HL/NHLBI NIH HHS; U01 HL063747-02/HL/NHLBI NIH HHS; U01 HL063747-03/HL/NHLBI NIH HHS; U01 HL063747-04/HL/NHLBI NIH HHS; U01 HL063747-05/HL/NHLBI NIH HHS; U01 HL063747-06/HL/NHLBI NIH HHS; U01 HL063747-06S1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Aldosterone Antagonists |
| Investigator | |
Investigator/Affiliation:
|
Christopher M O'Connor / ; Kerry L Lee / ; Stephen J Ellis / ; David S Rendall / ; David J Whellan / ; Ileana L Piña / ; Steven J Keteyian / ; Lawton S Cooper / ; Robin Boineau / ; Lawrence J Fine / ; Jerome L Fleg / ; Eric S Leifer / ; Virginia Erickson / ; Jonathan G Howlett / ; Nancy Houston Miller / ; Debra Isaac / ; Robert McKelvie / ; Faiez Zannad / ; Sharon Boozer / ; Patty Connolly / ; Anthony Doll / ; Stephen J Ellis / ; Camille Frazier / ; Deb Mark / ; Michelle McClanahan-Crowder / ; Marcia Meyer / ; Brenda S Mickley / ; David S Rendall / ; Molly Rich / ; Hoss Rostami / ; Sharon Settles / ; Kathy Spinella / ; Jessica Staib / ; Omar Thompson / ; William Abraham / ; Danuta Biniakiewicz / ; Joann Homan / ; Vera Bittner / ; Meredith Fitz-Gerald / ; Gregory Ewald / ; Heidi Craddock / ; Jean Flanagan / ; Gregg Fonarow / ; Virginia Erickson / ; Wilson Colucci / ; Nancy Z Lim / ; Elena Tokareva / ; Rami Alharethi / ; Ray Hershberger / ; Deirdre Nauman / ; Steven J Keteyian / ; Matthew Saval / ; Dalane W Kitzman / ; Brittney L Fray / ; Brian Moore / ; Ileana L Piña / ; Marianne Vest / ; Andrew Smith / ; Gail Snell / ; Eugene Wolfel / ; Mona Cantu / ; Kirkwood Adams / ; Jana Glotzer / ; Valerie Johnson / ; Kate Schumacher / ; Gordon Blackburn / ; Carrie Geither / ; Susan Moore / ; A Bleakley Chandler / ; Shanda Browning Vaughn / ; Paula J Easler / ; Debbie Williams / ; Marc Colmer / ; Julius M Gardin / ; Kelly Dimick / ; Sharon K Sklar / ; Sherri Teller / ; Jalal K Ghali / ; Karen Hale-Stenson / ; Mihai Gheorghiade / ; Theresa Strzelczyk / ; Maryl R Johnson / ; Cassondra Vander Ark / ; Lee R Goldberg / ; Andrew Kao / ; Jennifer Dekerlegand / ; William E Kraus / ; Johanna Johnson / ; Brian D Duscha / ; Mandeep R Mehra / ; Hector Ventura / ; Bobbett Harris / ; Monica Colvin-Adams / ; Kathy Duderstadt / ; Karen Meyer / ; Melissa Steger / ; Barry Cabuay / ; Ron Oren / ; Page Scovel / ; Andrew Kao / ; Tracey Stevens / ; Karen Haffey / ; Christy Mandacina / ; Ann Stewart / ; Ann M Swank / ; John Manire / ; Paul D Thompson / ; Ludmila Cosio-Lima / ; Marie Lagasse / ; Tehmina Naz / ; Lynne Wagoner / ; Susan K Roll / ; Frank G Yanowitz / ; Johnny Walker / ; Adam Mueller / ; Peter McCullough / ; Cathy Coleman / ; Kimberly A Dorrell / ; Tamika Washington / ; Eileen Handberg / ; James A Hill / ; Jacqueline Bakos / ; Alice Boyette / ; Pamela Smith / ; Cynthia Williams / ; Dalynn Badenhop / ; Susan Schroeder / ; Kelly Walter / ; Peter Kokkinos / ; Elisse Collins / ; Lauren Korsak / ; Eric Eichhorn / ; Allison Leonard / ; Tina Worley / ; Gerald Fletcher / ; Phil Peasley / ; Pam Oldano / ; John Kostis / ; Nora M Cosgrove / ; Udho Thadani / ; Lisa Rogan / ; Michelle Thresher / ; John Turner / ; Denise Barnard / ; Denise Herman / ; Annette Contasti / ; Marcy Sagerian / ; Elizabeth Ofili / ; Anekwe Onwuanyi / ; Sunday Nkemdiche / ; Howard Eisen / ; James Fitzpatrick / ; Joyce Wald / ; Jennie Wong / ; Myrvin Ellestad / ; Leslie Kern / ; Ezra A Amsterdam / ; Mary J Burns / ; Savitri Fedson / ; Ravi K Garg / ; Peggy Bennett / ; Linda Bond / ; Leway Chen / ; Janice Schrack / ; Douglas Pearce / ; Linda Bond / ; Greg Palevo / ; Margarett Serfass / ; Daniel Forman / ; Maria M Lopez / ; Yemi Talabi-Oates / ; April Williams / ; David Truitte / ; Cindy Baumann / ; Jenny Adams / ; Anne Lawrence / ; Dennis McNamara / ; Emily Gruendler / ; Virginia Schneider / ; Steven Hutchins / ; Alyce Hartwick / ; Paul Campbell / ; Michele Esposito / ; Carol Buchter / ; Rebecca A Letterer / ; Robert Taylor / ; Cheri Wells / ; Bruce Johnson / ; Beth Kaping / ; Susan Leathes / ; Joseph O'Bryan / ; Lynn Langley / ; Edward T Hastings / ; Cassandra Clancy / ; Neil Agruss / ; Christine Lawless / ; Robin Fortman / ; Timothy R McConnell / ; Deb Wantz / ; Mary N Walsh / ; Regina Margiotti / ; Stuart Russell / ; Elizabeth Heck / ; Justine Lachmann / ; Diane Lippman / ; Jeannette McLaughlin / ; Joel Landzberg / ; Susan Mathus / ; David W Cullinane / ; Wyatt Voyles / ; Dione Lenz / ; Scott Kaczkowski / ; Jack L David / ; Eve Gillespie / ; Pat Keane-Richmond / ; Steven K Krueger / ; Lori Heiss / ; Stephen Gottlieb / ; Nancy Greenberg / ; Neil Gordon / ; Emily Parks / ; Melanie Willoughby / ; Marvin W Kronenberg / ; Jennie Glenn / ; Carol Madison / ; Malcolm Arnold / ; Julie K Smith / ; Eduardo Azevedo / ; Glen Drobot / ; Estrellita Estrella-Holder / ; Jonathan Howlett / ; Darlene Cooley-Warnell / ; Sheila Yarn / ; Debra Isaac / ; Jane Grant / ; Kim Lyzun / ; Marie-Helene LeBlanc / ; Rachel Vienneau / ; Robert S McKelvie / ; Linda Beare / ; Jill Hancock / ; Gordon Moe / ; Delores Golob / ; Kenneth Melvin / ; Anne Cymet / ; Judith Renton / ; Anil Nigam / ; Julie LaLonge / ; Karim Djaballah / ; Patrick Aebehard / ; Marie Christine Iliou / ; Remi Sabatier / ; Annette Belin / ; Alain Cohen-Solal / ; Luc Hittinger / ; Bertram Pitt / ; Philip A Ades / ; Lotfy L Basta / ; Victor Froelicher / ; Mary Elizabeth Hamel / ; Barry M Massie / ; Lemuel Moyé / ; Lynda H Powell / ; William E Kraus / ; Johanna Johnson / ; Lucy Piner / ; Daniel Bensimhon / ; Stuart Russell / ; Julius M Gardin / ; Renee L Bess / ; Gerald I Cohen / ; Steven J Keteyian / ; Jonathan K Ehrman / ; Clinton A Brawner / ; Nancy Houston Miller / ; James A Blumenthal / ; Krista Barbour / ; Tanya M Spruill / ; Bess Marcus / ; Jim Raczynski / ; Kirkwood Adams / ; Mark Donahue / ; Mike Felker / ; Kevin A Schulman / ; Kevin P Weinfurt / ; Kathryn E Flynn / ; Shelby Reed / ; Ann Burnette / ; Linda Davidson-Ray / ; Joëlle Y Friedman / ; Yanhong Li / ; Li Lin / ; Betsy O'Neal / ; Michael Zile / ; Ralph H Johnson / ; Daniel R Bensimhon / ; Vera Bittner / ; Robin Boineau / ; Mark E Dunlap / ; William E Kraus / ; Christopher M O'Connor / ; Gordon Moe / ; John Wertheimer / ; David J Whellan / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Baseline differences in the HF-ACTION trial by sex.
Next Document: The relationship between body mass index and cardiopulmonary exercise testing in chronic systolic he...