Document Detail


New York Heart Association functional class influences the impact of diabetes on cardiac autonomic function.
MedLine Citation:
PMID:  20096854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Diabetes (D) and heart failure (HF) are associated with abnormal heart rate variability (HRV). It is unclear whether the HRV effect of having both is cumulative.
METHODS: Pretreatment HRV (traditional, nonlinear, and heart rate [HR] turbulence) in 80 D versus 74 non-D (ND) systolic HF patients was compared by New York Heart Association II versus III among patients entered into an HF drug evaluation study.
RESULTS: Age-adjusted HR was lower in class II D versus class III and most HRV including HR turbulence was better in class II ND versus all others, with few differences between class II D and class III ND and D patients.
CONCLUSION: The effect of D and HF on autonomic function may be cumulative in class II, but D may have little additional effect on most HRV in class III patients. The prognostic value of different HRV measures in D versus ND HF patients should be further investigated.
Authors:
Phyllis K Stein; Prakash Deedwania
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Publication Detail:
Type:  Clinical Trial, Phase II; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Journal of electrocardiology     Volume:  43     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-08-23     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-84     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Washington University School of Medicine, St. Louis, MO 63108, USA. pstein@im.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Autonomic Nervous System / physiopathology*
Diabetes Mellitus / physiopathology*
Electrocardiography, Ambulatory
Female
Heart Failure / physiopathology*
Heart Rate / physiology*
Humans
Male
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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