Document Detail


New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor.
MedLine Citation:
PMID:  11967329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alpha-dystroglycan (alpha-DG) has been identified as a major receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa virus, two Old World arenaviruses. The situation with New World arenaviruses is less clear: previous studies demonstrated that Oliveros virus also exhibited high-affinity binding to alpha-DG but that Guanarito virus did not. To extend these initial studies, several additional Old and New World arenaviruses were screened for entry into mouse embryonic stem cells possessing or lacking alpha-DG. In addition, representative viruses were further analyzed for direct binding to alpha-DG by means of a virus overlay protein blot assay technique. These studies indicate that Old World arenaviruses use alpha-DG as a major receptor, whereas, of the New World arenaviruses, only clade C viruses (i.e., Oliveros and Latino viruses) use alpha-DG as a major receptor. New World clade A and B arenaviruses, which include the highly pathogenic Machupo, Guanarito, Junin, and Sabia viruses, appear to use a different receptor or coreceptor for binding. Previous studies with LCMV have suggested the need for a small aliphatic amino acid at LCMV GP1 glycoprotein amino acid position 260 to allow high-affinity binding to alpha-DG. As reported herein, this requirement appears to be broadly applicable to the arenaviruses as determined by more extensive analysis of alpha-DG receptor usage and GP1 sequences of Old and New World arenaviruses. In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position.
Authors:
Christina F Spiropoulou; Stefan Kunz; Pierre E Rollin; Kevin P Campbell; Michael B A Oldstone
Related Documents :
21347389 - The varicella-zoster virus orf47 kinase interferes with host innate immune response by ...
21356589 - Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors.
21525349 - Delayed cytosolic exposure of japanese encephalitis virus double-stranded rna impedes i...
21173229 - Rna editing enzyme adenosine deaminase is a restriction factor for controlling measles ...
7904349 - Is cd4 sufficient for hiv entry? cell surface molecules involved in hiv infection.
21109369 - Characterization of an infectious pancreatic necrosis (ipn) virus carrier cell culture ...
1907999 - Defective presentation of endogenous antigens by a murine sarcoma. implications for the...
6255069 - Growth and release of several alphaviruses in chick and bhk cells.
21728819 - Rapid detection of lily symptomless virus with cdte quantum dots by flow cytometry.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  76     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-22     Completed Date:  2002-06-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5140-6     Citation Subset:  IM    
Affiliation:
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. ccs8@cdc.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Arenaviruses, New World / classification,  genetics,  physiology*
Arenaviruses, Old World / classification,  physiology
Cell Line
Cytoskeletal Proteins / metabolism,  physiology*
Dystroglycans
Dystrophin / metabolism,  physiology*
Glycoproteins / genetics
Membrane Glycoproteins / metabolism,  physiology*
Mice
Molecular Sequence Data
Phylogeny
Receptors, Virus / metabolism
Sequence Alignment
Stem Cells / metabolism,  virology*
Viral Envelope Proteins / genetics
Virus Replication
Grant Support
ID/Acronym/Agency:
AI-09484/AI/NIAID NIH HHS; AI-45927/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Dystrophin; 0/Glycoproteins; 0/Membrane Glycoproteins; 0/Receptors, Virus; 0/Viral Envelope Proteins; 146888-27-9/Dystroglycans
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scr...
Next Document:  Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelo...