Document Detail

New triterpene saponins from Duranta repens Linn. and their cytotoxic activity.
MedLine Citation:
PMID:  19471216     Owner:  NLM     Status:  MEDLINE    
From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, (1)H-, (13)C-NMR, (1)H-(1)H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.
Wafaa S Ahmed; Mona A Mohamed; Rabab A El-Dib; Manal M Hamed
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Publication Detail:
Type:  Journal Article     Date:  2009-05-25
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  14     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-07-22     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1952-65     Citation Subset:  IM    
Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt.
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MeSH Terms
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology
Artemia / drug effects*
Carbohydrate Conformation
Carbohydrate Sequence
Cell Line, Tumor / drug effects*
Drug Screening Assays, Antitumor
Molecular Sequence Data
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry
Saponins* / chemistry,  isolation & purification,  pharmacology
Triterpenes* / chemistry,  isolation & purification,  pharmacology
Verbenaceae / anatomy & histology,  chemistry*
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Saponins; 0/Triterpenes

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