| A New Triterpene From Uncaria macrophylla and Its Antitumor Activity. | |
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MedLine Citation:
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PMID: 22334066 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC(50) values of 78.2 µg/mL and 73.9 µg/mL. |
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Authors:
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Guangli Sun; Xiaopo Zhang; Xudong Xu; Junshan Yang; Mingliang Zhong; Jingquan Yuan |
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Publication Detail:
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Type: Journal Article Date: 2012-02-14 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 17 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1883-9 Citation Subset: IM |
Affiliation:
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Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. xdxu@implad.ac.cn. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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