| A New Tool to Detect Kidney Disease in Chinese Type 2 Diabetes Patients-Comparison of EZSCAN with Standard Screening Methods. | |
| | |
MedLine Citation:
|
PMID: 21714678 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Background: EZSCAN(®) (Impeto Medical, Paris, France), a noninvasive device that assesses sweat gland dysfunction using reverse iontophoresis, also detects early dysglycemia. Given the interrelationships among dysglycemia, vasculopathy, and neuropathy, EZSCAN may detect kidney disease in diabetes (DKD). Methods: An EZSCAN score (0-100) was calculated using a proprietary algorithm based on the chronoamperometry analysis. We measured the score in 50 Chinese type 2 diabetes patients without DKD (urinary albumin-creatinine ratio [ACR] <2.5 mg/mmol in men or ACR <3.5 mg/mmol in women and estimated glomerular filtration rate [eGFR] >90 mL/min/1.73 m(2)) and 50 with DKD (ACR ≥25 mg/mmol and eGFR <60 mL/min/1.73 m(2)). We used spline analysis to determine the threshold value of the score in detecting DKD and its sensitivity and specificity. Results: EZSCAN scores were highly correlated with log values of eGFR (r=0.67, P<0.0001) and ACR (r=-0.66, P<0.0001). Using a cutoff value of 55, the score had 94% sensitivity, 78% specificity, and a likelihood ratio of 4.2 to detect DKD with a positive predictive value of 81% and a negative predictive value of 93%. On multivariable analysis, DKD was independently associated with EZSCAN score (β=-0.72, P=0.02), smoking status (1=never, 0=current/former) (β=-2.37, P=0.02), retinopathy (1=yes, 0=no) (β=3.019, P=0.01), triglycerides (β=2.56, P=0.013), and blood hemoglobin (β=-0.613, P=0.04). Patients without DKD but low EZSCAN score (n=10) had longer duration of disease (median [interquartile range], 13 [9-17] vs. 8 [4-16] years; P=0.017) and were more likely to have retinopathy (36.7% vs. 5.1%, P=0.02), lower eGFR (98 [95.00-103] vs. 106 [98.5-115], P=0.036), and treatment with renin-angiotensin system blockers (81.8% vs. 25.6%, P=0.002) than those with a normal score. Conclusion: EZSCAN may detect high-risk subjects for DKD in Chinese populations. |
| | |
Authors:
|
Risa Ozaki; Kitty K T Cheung; Enoch Wu; Alice Kong; Xilin Yang; Eric Lau; Philippe Brunswick; Jean-Henri Calvet; Jean-Paul Deslypere; Juliana C N Chan |
Related Documents
:
|
21955218 - Thrombin generation in type 2 diabetes with albuminuria and macrovascular disease. 16178908 - Carbohydrate-deficient isoforms of transferrin (%cdt) and sialic acid (sa) in iron-defi... 9406078 - Effects of a duodenal glucose infusion on the relationship between plasma concentration... 16935308 - A compartmental model of iron regulation in the mouse. 16809878 - Racial disparity in the diagnosis of obesity among people with diabetes. 2654938 - Sequence, tissue distribution, and differential expression of mrna for a putative insul... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-29 |
Journal Detail:
|
Title: Diabetes technology & therapeutics Volume: - ISSN: 1557-8593 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100889084 Medline TA: Diabetes Technol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Department of Medicine & Therapeutics and Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong , The Prince of Wales Hospital, Hong Kong SAR, China . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of Ambient Temperature on Analytical Performance of Self-Monitoring Blood Glucose Systems.
Next Document: Glycemic Control and Pregnancy Outcomes in Women with Type 1 Diabetes Mellitus Using Lispro Versus R...