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New Thrombolytic Agents: Does Direct Angioplasty Still Have a Role?
MedLine Citation:
PMID:  11096674     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The optimal method of reperfusion for patients with ST-segment elevation acute myocardial infarction has been a point of controversy over the last two decades. Tenecteplase and reteplase are comparable to accelerated-dose alteplase but more convenient because they can be delivered as a bolus. Combination regimens represent a further advance in reperfusion therapy; planned and ongoing studies will evaluate the clinical efficacy and safety of combination therapy. Promising early results of primary coronary intervention with glycoprotein IIb/IIIa receptor inhibition have been reported, and this strategy may emerge as a mainstay of therapy at hospitals with on-site interventional facilities. A possible future approach that could be universally applied consists of combination therapy and adjunctive/rescue percutaneous intervention in selected patients.
Authors:
Llevadot; Giugliano
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Current interventional cardiology reports     Volume:  2     ISSN:  1534-3103     ISO Abbreviation:  Curr Interv Cardiol Rep     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888981     Medline TA:  Curr Interv Cardiol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  250-257     Citation Subset:  -    
Affiliation:
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. rgiugliano@rics.bwh.harvard.edu
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