| A new system for determining the causes of stillbirth. | |
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MedLine Citation:
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PMID: 20664383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the methods for assigning the cause of death for stillbirths enrolled in the Stillbirth Collaborative Research Network (SCRN). METHODS: A complete evaluation, including postmortem examination, placental pathology, medical record abstraction, and maternal interview was available on 512 stillbirths among 500 women. These 512 stillbirths were evaluated for cause of death using the definitions outlined in this report. Using the best available evidence, SCRN investigators developed a new methodology to assign the cause of death of stillbirths using clinical, postmortem, and placental pathology data. This new tool, designated the Initial Causes of Fetal Death, incorporates known causes of death and assigns them as possible or probable based on strict diagnostic criteria, derived from published references and pathophysiologic sequences that lead to stillbirth. RESULTS: Six broad categories of causes of death are accounted for, including maternal medical conditions; obstetric complications; maternal or fetal hematologic conditions; fetal genetic, structural, and karyotypic abnormalities; placental infection, fetal infection, or both; and placental pathologic findings. Isolated histologic chorioamnionitis and small for gestational age were not considered causes of death. CONCLUSION: A new system, Initial Causes of Fetal Death, to assign cause of death in stillbirths was developed by the SCRN investigators for use in this study but has broader applicability. Initial Causes of Fetal Death is a standardized method to assign probable and possible causes of death of stillbirths based on information routinely collected during prenatal care and the clinical evaluation of fetal death. |
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Authors:
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Donald J Dudley; Robert Goldenberg; Deborah Conway; Robert M Silver; George R Saade; Michael W Varner; Halit Pinar; Donald Coustan; Radek Bukowski; Barbara Stoll; Matthew A Koch; Corette B Parker; Uma M Reddy; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 116 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 254-60 Citation Subset: AIM; IM |
Affiliation:
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University of Texas Health Science Center at San Antonio, Texas 78229, USA. dudleyd@uthscsa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diseases in Twins Female Fetal Death / etiology* Humans Infant, Newborn Pregnancy Stillbirth* |
| Grant Support | |
ID/Acronym/Agency:
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U01-HD-45954/HD/NICHD NIH HHS; U10-HD045925/HD/NICHD NIH HHS; U10-HD045944/HD/NICHD NIH HHS; U10-HD045952/HD/NICHD NIH HHS; U10-HD045953/HD/NICHD NIH HHS; U10-HD045955/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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